Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy

Abstract Background Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathw...

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Bibliographic Details
Main Authors: Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf, Jia-Yi Li
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Translational Neurodegeneration
Subjects:
chaperone-mediated autophagy
macroautophagy
alpha-synuclein
protein aggregation
Parkinson disease
lysosomal-associated membrane protein
Online Access:http://link.springer.com/article/10.1186/s40035-019-0159-7

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http://link.springer.com/article/10.1186/s40035-019-0159-7

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