Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
Abstract Background Progressive accumulation of α-synuclein is a key step in the pathological development of Parkinson’s disease. Impaired protein degradation and increased levels of α-synuclein may trigger a pathological aggregation in vitro and in vivo. The chaperone-mediated autophagy (CMA) pathw...
Main Authors: | Jia-Zhen Wu, Mustafa Ardah, Caroline Haikal, Alexander Svanbergsson, Meike Diepenbroek, Nishant N. Vaikath, Wen Li, Zhan-You Wang, Tiago F. Outeiro, Omar M. El-Agnaf, Jia-Yi Li |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-06-01
|
Series: | Translational Neurodegeneration |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40035-019-0159-7 |
Similar Items
-
E46K Mutant α-Synuclein Is Degraded by Both Proteasome and Macroautophagy Pathway
by: Jia-qing Yan, et al.
Published: (2018-11-01) -
The Molecular Chaperone DNAJB6, but Not DNAJB1, Suppresses the Seeded Aggregation of Alpha-Synuclein in Cells
by: Natasja Deshayes, et al.
Published: (2019-09-01) -
Macroautophagy in sporadic and the genetic form of Parkinson's disease with the A53T α-synuclein mutation
by: Huang Yue, et al.
Published: (2012-01-01) -
Molecular chaperones in the assembly of α-Synuclein and Parkinson’s Disease
by: Pemberton, Samantha
Published: (2011) -
Cathepsin Oxidation Alters Alpha-Synuclein Processing
by: Andrew W. Ferree
Published: (2019-05-01)