Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice

Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice

The combined/synergistic effect of genetic mutation of KRAS in the pancreas and obesity, a life-style factor on suppression of natural killer (NK) cells at the pre-neoplastic stage of pancreatic cancer has not been investigated and is the subject of this report. Obese mice with KRAS (KC) mutation in...

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Bibliographic Details
Main Authors: Kawaljit Kaur, Hui-Hua Chang, Paytsar Topchyan, Jessica Morgan Cook, Andre Barkhordarian, Guido Eibl, Anahid Jewett
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
KRAS
IFN-γ
HFCD
control diet
pre-neoplastic lesions
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01229/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01229/full

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