Protective Effects of Controlled Mechanical Loading of Bone in C57BL6/J Mice Subject to Disuse

ABSTRACT Prolonged reduction in weightbearing causes bone loss. Disuse of bone is associated with recovery from common musculoskeletal injury and trauma, bed rest resulting from various medical conditions, and spaceflight. The hindlimb‐suspension rodent model is popular for simulating unloading and...

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Bibliographic Details
Main Authors: Alex DeLong, Michael A Friedman, Scott M Tucker, Andrew R Krause, Allen Kunselman, Henry J Donahue, Gregory S Lewis
Format: Article
Language:English
Published: Wiley 2020-03-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10322