Design, Synthesis and Biological Evaluation of 7-Chloro-9<i>H</i>-pyrimido[4,5-<i>b</i>]indole-based Glycogen Synthase Kinase-3β Inhibitors

Design, Synthesis and Biological Evaluation of 7-Chloro-9<i>H</i>-pyrimido[4,5-<i>b</i>]indole-based Glycogen Synthase Kinase-3β Inhibitors

Glycogen synthase kinase-3&#946; (GSK-3&#946;) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer&#8217;s disease. We herein report on the optimization of a novel class of GSK-3&#946; inhibitors based on the tofacitinib-derived sc...

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Bibliographic Details
Main Authors: Stanislav Andreev, Tatu Pantsar, Francesco Ansideri, Mark Kudolo, Michael Forster, Dieter Schollmeyer, Stefan A. Laufer, Pierre Koch
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
Glycogen synthase kinase-3β
7-chloro-9<i>H</i>-pyrimido[4,5-<i>b</i>]indole
protein kinase
kinase inhibitor
tofacitinib
Online Access:https://www.mdpi.com/1420-3049/24/12/2331

Internet

https://www.mdpi.com/1420-3049/24/12/2331

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