Design, Synthesis and Biological Evaluation of 7-Chloro-9<i>H</i>-pyrimido[4,5-<i>b</i>]indole-based Glycogen Synthase Kinase-3β Inhibitors
Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer’s disease. We herein report on the optimization of a novel class of GSK-3β inhibitors based on the tofacitinib-derived sc...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-06-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/24/12/2331 |