Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients

Prevalence of ESR1 E380Q mutation in tumor tissue and plasma from Japanese breast cancer patients

Abstract Background ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one of the ESR1 mutations, is associated with estradiol (E2) hypersensitivity, increased DNA binding...

Full description

Bibliographic Details
Main Authors: Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Aiko Sueta, Mai Tomiguchi, Keiichi Murakami, Yoko Omoto, Hirotaka Iwase
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Cancer
Subjects:
Metastatic breast cancer
Acquired endocrine therapy resistance
ESR1 mutations
E380Q mutation
Cell-free DNA
Online Access:http://link.springer.com/article/10.1186/s12885-017-3779-2

Internet

http://link.springer.com/article/10.1186/s12885-017-3779-2

Similar Items