The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α

The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α

Summary: The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis. We show that the negative circadian regulator CRY1 is also a negative regulator of hypoxia-inducible...

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Main Authors: Elitsa Y. Dimova, Mirza Jakupovic, Kateryna Kubaichuk, Daniela Mennerich, Tabughang Franklin Chi, Filippo Tamanini, Małgorzata Oklejewicz, Jens Hänig, Nadiya Byts, Kari A. Mäkelä, Karl-Heinz Herzig, Peppi Koivunen, Ines Chaves, Gijsbertus van der Horst, Thomas Kietzmann
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219300616

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http://www.sciencedirect.com/science/article/pii/S2589004219300616

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