Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute‐On‐Chronic Liver Failure

Switching from Fatty Acid Oxidation to Glycolysis Improves the Outcome of Acute‐On‐Chronic Liver Failure

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Abstract Acute‐on‐chronic liver failure (ACLF) has a high mortality rate. Metabolic reprogramming is an important mechanism for cell survival. Herein, the metabolic patterns of ACLF patients are analyzed. An in vitro model of ACLF is established using Chang liver cells under hyperammonemia and hypox...

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Bibliographic Details
Main Authors: Zujiang Yu, Jingjing Li, Zhigang Ren, Ranran Sun, Yang Zhou, Qi Zhang, Qiongye Wang, Guangying Cui, Juan Li, Ang Li, Zhenfeng Duan, Yuming Xu, Zhichao Wang, Peiyuan Yin, Hailong Piao, Jun Lv, Xiaorui Liu, Yanfang Wang, Ming Fang, Zhengping Zhuang, Guowang Xu, Quancheng Kan
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Advanced Science
Subjects:
acute‐on‐chronic liver failure
hepatocytes
hypoxia
metabolic reprogramming
Online Access:https://doi.org/10.1002/advs.201902996

Internet

https://doi.org/10.1002/advs.201902996

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