Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro.

Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro.

BACKGROUND: In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for articular cartilage derangement. This study was aimed at providing further insight into the impairment of the anabolic cytokine...

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Bibliographic Details
Main Authors: Elisa Assirelli, Lia Pulsatelli, Paolo Dolzani, Daniela Platano, Eleonora Olivotto, Giuseppe Filardo, Giovanni Trisolino, Andrea Facchini, Rosa Maria Borzì, Riccardo Meliconi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018406?pdf=render

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http://europepmc.org/articles/PMC4018406?pdf=render

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