Use of propensity score matching to create counterfactual group to assess potential HIV prevention interventions

Abstract The design of HIV prevention trials in the context of effective HIV preventive methods is a challenge. Alternate designs, including using non-randomised ‘observational control arms’ have been proposed. We used HIV simulated vaccine efficacy trials (SiVETs) to show pitfalls that may arise fr...

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Bibliographic Details
Main Authors: Andrew Abaasa, Yunia Mayanja, Gershim Asiki, Matt A. Price, Patricia E. Fast, Eugene Ruzagira, Pontiano Kaleebu, Jim Todd
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86539-x