Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis.

Toxoplasma gondii is a human pathogen prevalent worldwide that poses a challenging and unmet need for novel treatment of toxoplasmosis. Using a semi-automated reconstruction algorithm, we reconstructed a genome-scale metabolic model, ToxoNet1. The reconstruction process and flux-balance analysis of...

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Bibliographic Details
Main Authors: Stepan Tymoshenko, Rebecca D Oppenheim, Rasmus Agren, Jens Nielsen, Dominique Soldati-Favre, Vassily Hatzimanikatis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4441489?pdf=render