Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300...
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doaj-58180d77a93143768541f3c3145e5cfe2020-11-25T01:11:31ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592015-02-0121224225010.3201/eid2102.140795Microbiota That Affect Risk for Shigellosis in Children in Low-Income CountriesBrianna LindsayJoe OundoM. Anowar HossainMartin AntonioBoubou TambouraAlan W. WalkerJoseph N. PaulsonJulian ParkhillRichard OmoreAbu S.G. FaruqueSuman Kumar DasUsman N. IkumapayiMitchell AdeyemiDoh SanogoDebasish SahaSamba SowTamer H. FaragDilruba NasrinShan LiSandra PanchalingamMyron M. LevineKaren KotloffLaurence S. MagderLaura HungerfordHalvor SommerfeltMihai PopJames P. NataroO. Colin StinePathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene.https://wwwnc.cdc.gov/eid/article/21/2/14-0795_articleshigellosisShigellabacteriapolymicrobial infectionEscherichia colienteroinvasive E. coli |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine |
spellingShingle |
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries Emerging Infectious Diseases shigellosis Shigella bacteria polymicrobial infection Escherichia coli enteroinvasive E. coli |
author_facet |
Brianna Lindsay Joe Oundo M. Anowar Hossain Martin Antonio Boubou Tamboura Alan W. Walker Joseph N. Paulson Julian Parkhill Richard Omore Abu S.G. Faruque Suman Kumar Das Usman N. Ikumapayi Mitchell Adeyemi Doh Sanogo Debasish Saha Samba Sow Tamer H. Farag Dilruba Nasrin Shan Li Sandra Panchalingam Myron M. Levine Karen Kotloff Laurence S. Magder Laura Hungerford Halvor Sommerfelt Mihai Pop James P. Nataro O. Colin Stine |
author_sort |
Brianna Lindsay |
title |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries |
title_short |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries |
title_full |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries |
title_fullStr |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries |
title_full_unstemmed |
Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries |
title_sort |
microbiota that affect risk for shigellosis in children in low-income countries |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2015-02-01 |
description |
Pathogens in the gastrointestinal tract exist within a vast population of microbes. We examined associations between pathogens and composition of gut microbiota as they relate to Shigella spp./enteroinvasive Escherichia coli infection. We analyzed 3,035 stool specimens (1,735 nondiarrheal and 1,300 moderate-to-severe diarrheal) from the Global Enteric Multicenter Study for 9 enteropathogens. Diarrheal specimens had a higher number of enteropathogens (diarrheal mean 1.4, nondiarrheal mean 0.95; p<0.0001). Rotavirus showed a negative association with Shigella spp. in cases of diarrhea (odds ratio 0.31, 95% CI 0.17–0.55) and had a large combined effect on moderate-to-severe diarrhea (odds ratio 29, 95% CI 3.8–220). In 4 Lactobacillus taxa identified by 16S rRNA gene sequencing, the association between pathogen and disease was decreased, which is consistent with the possibility that Lactobacillus spp. are protective against Shigella spp.–induced diarrhea. Bacterial diversity of gut microbiota was associated with diarrhea status, not high levels of the Shigella spp. ipaH gene. |
topic |
shigellosis Shigella bacteria polymicrobial infection Escherichia coli enteroinvasive E. coli |
url |
https://wwwnc.cdc.gov/eid/article/21/2/14-0795_article |
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