Ligation bias in illumina next-generation DNA libraries: implications for sequencing ancient genomes.

Ligation bias in illumina next-generation DNA libraries: implications for sequencing ancient genomes.

Ancient DNA extracts consist of a mixture of endogenous molecules and contaminant DNA templates, often originating from environmental microbes. These two populations of templates exhibit different chemical characteristics, with the former showing depurination and cytosine deamination by-products, re...

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Bibliographic Details
Main Authors: Andaine Seguin-Orlando, Mikkel Schubert, Joel Clary, Julia Stagegaard, Maria T Alberdi, José Luis Prado, Alfredo Prieto, Eske Willerslev, Ludovic Orlando
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3812280?pdf=render

Internet

http://europepmc.org/articles/PMC3812280?pdf=render

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