Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

Abstract Background Succinate dehydrogenase (SDH) loss and mastermind-like 3 (MAML3) translocation are two clinically important genetic alterations that correlate with increased rates of metastasis in subtypes of human paraganglioma and pheochromocytoma (PPGL) neuroendocrine tumors. Although hypothe...

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Bibliographic Details
Main Authors: John A. Smestad, L. James Maher
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Paraganglioma
Pheochromocytoma
Succinate dehydrogenase
von Hippel-Lindau
Mastermind-like transcriptional coactivator 3
Transcriptional network
Online Access:http://link.springer.com/article/10.1186/s12885-019-5813-z

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http://link.springer.com/article/10.1186/s12885-019-5813-z

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