Clinical Genotyping of Non–Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes

Clinical Genotyping of Non–Small Cell Lung Cancers Using Targeted Next-Generation Sequencing: Utility of Identifying Rare and Co-mutations in Oncogenic Driver Genes

Detection of somatic mutations in non–small cell lung cancers (NSCLCs), especially adenocarcinomas, is important for directing patient care when targeted therapy is available. Here, we present our experience with genotyping NSCLC using the Ion Torrent Personal Genome Machine (PGM) and the AmpliSeq C...

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Bibliographic Details
Main Authors: Laura J. Tafe, Kirsten J. Pierce, Jason D. Peterson, Francine de Abreu, Vincent A. Memoli, Candice C. Black, Jason R. Pettus, Jonathan D. Marotti, Edward J. Gutmann, Xiaoying Liu, Keisuke Shirai, Konstantin H. Dragnev, Christopher I. Amos, Gregory J. Tsongalis
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616301282

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http://www.sciencedirect.com/science/article/pii/S1476558616301282

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