Identification of ACAT1- and ACAT2-specific inhibitors using a novel, cell-based fluorescence assay

Acyl CoA:cholesterol acyltransferase 1 (ACAT1) and ACAT2 are enzymes responsible for the formation of cholesteryl esters in tissues. While both ACAT1 and ACAT2 are present in the liver and intestine, the cells containing either enzyme within these tissues are distinct, suggesting that ACAT1 and ACAT...

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Bibliographic Details
Main Authors: Aaron T. Lada, Matthew Davis, Carol Kent, James Chapman, Hiroshi Tomoda, Satoshi Omura, Lawrence L. Rudel
Format: Article
Language:English
Published: Elsevier 2004-02-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520319106