Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice

Nxf7 deficiency impairs social exploration and spatio-cognitive abilities as well as hippocampal synaptic plasticity in mice

Nuclear RNA export factors (NXF) are conserved in all metazoans and are deemed essential for shuttling RNA across the nuclear envelope and other post-transcriptional processes (such as mRNA metabolism, storage and stability). Disruption of human NXF5 has been implicated in intellectual and psychoso...

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Bibliographic Details
Main Authors: Zsuzsanna eCallaerts-Vegh, Tariq eAhmed, Ben eVermaercke, Peter eMarynen, Detlef eBalschun, Guy eFroyen, Rudi eD'Hooge
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Hippocampus
Spatial learning
mouse models
LTP and LTD
Nuclear RNA export factors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00179/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00179/full

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