Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome

Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome

WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3. In humans, WHSC1 haploinsufficiency is associated with all known cases of Wolf-Hirschhorn syndrome (WHS). The cardinal feature of WHS is a craniofacial dysmorphism, which is accompanied...

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Bibliographic Details
Main Authors: Mohi Ahmed, Kiyoe Ura, Andrea Streit
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
Deafness
Ear
Hair cells
Histone modification
Methyltransferase
Mouse
Stereocilia
Online Access:http://dmm.biologists.org/content/8/9/1027

Internet

http://dmm.biologists.org/content/8/9/1027

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