Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes.

INTRODUCTION: Rheumatoid arthritis (RA) is an inflammatory disease of the joint characterized by chronic synovitis causing pain, swelling and loss of function due to destruction of cartilage and bone. The complex series of pathological events occurring in RA is largely regulated via excessive produc...

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Bibliographic Details
Main Authors: Randi M Sommerfelt, Astrid J Feuerherm, Kymry Jones, Berit Johansen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3861525?pdf=render