Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

The M2 proton channel of the influenza A virus is the target of the anti-influenza drugs amantadine and rimantadine. The effectiveness of these drugs has been dramatically limited by the rapid spread of drug resistant mutations, mainly at sites S31N, V27A and L26F in the pore of the channel. Despite...

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Bibliographic Details
Main Authors: Aruna D Balgi, Jun Wang, Daphne Y H Cheng, Chunlong Ma, Tom A Pfeifer, Yoko Shimizu, Hilary J Anderson, Lawrence H Pinto, Robert A Lamb, William F DeGrado, Michel Roberge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3562233?pdf=render

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http://europepmc.org/articles/PMC3562233?pdf=render

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