Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure.

Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure.

Vγ9Vδ2 T cells rapidly respond to phosphoantigens produced by Plasmodium falciparum in an innate-like manner, without prior antigen exposure or processing. Vδ2 T cells have been shown to inhibit parasite replication in vitro and are associated with protection from P. falciparum parasitemia in vivo....

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Bibliographic Details
Main Authors: Lila A Farrington, Perri C Callaway, Hilary M Vance, Kayla Baskevitch, Emma Lutz, Lakshmi Warrier, Tara I McIntyre, Rachel Budker, Prasanna Jagannathan, Felistas Nankya, Kenneth Musinguzi, Mayimuna Nalubega, Ester Sikyomu, Kate Naluwu, Emmanuel Arinaitwe, Grant Dorsey, Moses R Kamya, Margaret E Feeney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008997

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https://doi.org/10.1371/journal.ppat.1008997

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