p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish.

p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish.

p63 is a multi-isoform member of the p53 family of transcription factors. There is compelling genetic evidence that ΔNp63 isoforms are needed for keratinocyte proliferation and stemness in the developing vertebrate epidermis. However, the role of TAp63 isoforms is not fully understood, and TAp63 kno...

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Bibliographic Details
Main Authors: Boris Fischer, Manuel Metzger, Rebecca Richardson, Philipp Knyphausen, Thomas Ramezani, Rainer Franzen, Elmon Schmelzer, Wilhelm Bloch, Thomas J Carney, Matthias Hammerschmidt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3886889?pdf=render

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http://europepmc.org/articles/PMC3886889?pdf=render

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