Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization

Codon Harmonization of a Kir3.1-KirBac1.3 Chimera for Structural Study Optimization

The expression of functional, folded, and isotopically enriched membrane proteins is an enduring bottleneck for nuclear magnetic resonance (NMR) studies. Indeed, historically, protein yield optimization has been insufficient to allow NMR analysis of many complex Eukaryotic membrane proteins. However...

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Bibliographic Details
Main Authors: Evan Van Aalst, Maryam Yekefallah, Anil K. Mehta, Isaac Eason, Benjamin Wylie
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
codon harmonization
nuclear magnetic resonance (nmr)
codon bias
protein folding
protein expression
k<sup>+</sup> channels
Online Access:https://www.mdpi.com/2218-273X/10/3/430

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https://www.mdpi.com/2218-273X/10/3/430

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