Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs

Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs

Ten-eleven translocation (Tet) family proteins convert 5-methylcytosine to 5-hydroxymethylcytosine. We show that mouse embryonic stem cells (ESCs) depleted of Tet1 and/or Tet2 by RNAi exhibit short telomeres and chromosomal instability, concomitant with reduced telomere recombination. Tet1 and Tet2 ...

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Bibliographic Details
Main Authors: Jiao Yang, Renpeng Guo, Hua Wang, Xiaoying Ye, Zhongcheng Zhou, Jiameng Dan, Haiying Wang, Peng Gong, Wei Deng, Yu Yin, ShiQing Mao, Lingbo Wang, Junjun Ding, Jinsong Li, David L. Keefe, Meelad M. Dawlaty, Jianlong Wang, GuoLiang Xu, Lin Liu
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Subjects:
Tet
DNA methylation
embryonic stem cells
telomere
pluripotency
Dnmt3b
Zscan4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305022

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http://www.sciencedirect.com/science/article/pii/S2211124716305022

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