Homogeneous Time-Resolved Fluorescence-Based Assay to Monitor Extracellular Signal-Regulated Kinase Signalling in a High-Throughput Format

Homogeneous Time-Resolved Fluorescence-Based Assay to Monitor Extracellular Signal-Regulated Kinase Signalling in a High-Throughput Format

The extracellular signal-regulated kinases (ERKs) are key components of multiple important cell signalling pathways regulating diverse biological responses. This signalling is characterized by phosphorylation cascades leading to ERK1/2 activation and promoted by various cell surface receptors includ...

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Bibliographic Details
Main Authors: Mohammed Akli eAyoub, Julien eTrebaux, Julie eVallaghe, Fabienne eCharrier-Savournin, Khaled eAl-Hosaini, Arturo eGonzalez-Moya, Jean-Philippe R Pin, Kevin D G Pfleger, Eric eTrinquet
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Endocrinology
Subjects:
GPCR
RTK
ERK1/2
EGFR.
HTRF®
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00094/full

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