Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In the pre...

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Bibliographic Details
Main Authors: Albertus Eka Yudistira Sarwono, Shinya Mitsuhashi, Mohammad Hazzaz Bin Kabir, Kengo Shigetomi, Tadashi Okada, Fumina Ohsaka, Satoko Otsuguro, Katsumi Maenaka, Makoto Igarashi, Kentaro Kato, Makoto Ubukata
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
drug repurposing
imp dehydrogenase
irreversible inhibitors
purine metabolic pathway
Online Access:http://dx.doi.org/10.1080/14756366.2018.1540474

Internet

http://dx.doi.org/10.1080/14756366.2018.1540474

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