Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks

Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks

Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated. Synapse function relies on the microtubule (MT) cytoskeleton, the dynamics of...

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Bibliographic Details
Main Authors: Peter Verstraelen, Jan R. Detrez, Marlies Verschuuren, Jacobine Kuijlaars, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microtubule
primary hippocampal neuron
neuronal network
synapse
P301L
Tau aggregation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00173/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00173/full

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