Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting

Intracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting

Abstract Cytoskeletal-associated proteins play an active role in coordinating the adhesion and migration machinery in cancer progression. To identify functional protein networks and potential inhibitors, we screened an internalizing phage (iPhage) display library in tumor cells, and selected LGRFYAA...

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Main Authors: Daniela I. Staquicini, Roberto Rangel, Liliana Guzman-Rojas, Fernanda I. Staquicini, Andrey S. Dobroff, Christy A. Tarleton, Michelle A. Ozbun, Mikhail G. Kolonin, Juri G. Gelovani, Serena Marchiò, Richard L. Sidman, Katherine A. Hajjar, Wadih Arap, Renata Pasqualini
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03470-w

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https://doi.org/10.1038/s41598-017-03470-w

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