Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...

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Bibliographic Details
Main Authors: Guihua Sun, Spencer Yele Yeh, Christine Wan-Yin Yuan, Margaret Jean-Yih Chiu, Bryan Shing Hei Yung, Yun Yen
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Ago2
agshRNA
agsiRNA
RNAi
siRNA
sliced siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300051

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http://www.sciencedirect.com/science/article/pii/S2162253116300051

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