Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Uncoupling Splicing From Transcription Using Antisense Oligonucleotides Reveals a Dual Role for I Exon Donor Splice Sites in Antibody Class Switching

Class switch recombination (CSR) changes antibody isotype by replacing Cμ constant exons with different constant exons located downstream on the immunoglobulin heavy (IgH) locus. During CSR, transcription through specific switch (S) regions and processing of non-coding germline transcripts (GLTs) ar...

Full description

Bibliographic Details
Main Authors: Anne Marchalot, Mohamad Omar Ashi, Jean-Marie Lambert, Claire Carrion, Sandrine Lecardeur, Nivine Srour, Laurent Delpy, Soazig Le Pennec
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
B cells
class switch recombination
splicing
germline transcripts
I exon
antisense oligonucleotides
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00780/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00780/full

Similar Items