Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases

Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases

Available evidence suggests that diabetes mellitus (DM) is a non-genetic risk factor for Parkinson’s disease (PD). PD and DM have shared similarities in pathogenetic mechanisms, including age, environmental factors, inflammatory reaction, and protein aggregation, etc. α-Synuclein is the primary prot...

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Bibliographic Details
Main Authors: Yan Sun, Chuang Guo, Lin Yuan, Wen Li, Zhan-You Wang, Feng Yue, Jia-Yi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Neuroscience
Subjects:
diabetes mellitus
Parkinson’s disease
α-synuclein
IAPP
protein aggregation
synucleinopathies
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00063/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00063/full

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