Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial aggregation studies. The genetic contribution to severe...

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Bibliographic Details
Main Authors: Sana Amanat, Alvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas‐Caletrio, Barbara Canlon, Patrick May, Christopher R. Cederroth, Jose A. Lopez-Escamez
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:EBioMedicine
Subjects:
Tinnitus
Extreme phenotype
Axon initial segment
Exome sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642100102X

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http://www.sciencedirect.com/science/article/pii/S235239642100102X

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