A Novel Chromosomal Translocation Identified due to Complex Genetic Instability in iPSC Generated for Choroideremia

A Novel Chromosomal Translocation Identified due to Complex Genetic Instability in iPSC Generated for Choroideremia

Induced pluripotent stem cells (iPSCs) have revolutionized the study of human diseases as they can renew indefinitely, undergo multi-lineage differentiation, and generate disease-specific models. However, the difficulty of working with iPSCs is that they are prone to genetic instability. Furthermore...

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Bibliographic Details
Main Authors: Nejla Erkilic, Vincent Gatinois, Simona Torriano, Pauline Bouret, Carla Sanjurjo-Soriano, Valerie De Luca, Krishna Damodar, Nicolas Cereso, Jacques Puechberty, Rocio Sanchez-Alcudia, Christian P. Hamel, Carmen Ayuso, Isabelle Meunier, Franck Pellestor, Vasiliki Kalatzis
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
induced pluripotent stem cells
genetic instability
retinal differentiation
inherited retinal dystrophies
choroideremia
underprenylated cell phenotype
Online Access:https://www.mdpi.com/2073-4409/8/9/1068

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https://www.mdpi.com/2073-4409/8/9/1068

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