Mutation-Derived Neoantigens for Cancer Immunotherapy

Mutation-Derived Neoantigens for Cancer Immunotherapy

Mutation-derived neoantigens distinguish tumor from normal cells. T cells can sense the HLA-presented mutations, recognize tumor cells as non-self and destroy them. Therapeutically, immunotherapy antibodies can increase the virulence of the immune system by increasing T-cell cytotoxicity targeted to...

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Bibliographic Details
Main Authors: John C. Castle, Mohamed Uduman, Simarjot Pabla, Robert B. Stein, Jennifer S. Buell
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
cancer
mutations
neoantigens
immunotherapy
therapeutic vaccine
TCR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01856/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01856/full

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