NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture.

NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture.

Sepsis is characterized by organ dysfunction due to a dysregulated immune response to infection. Currently, no effective treatment for sepsis exists. Platelets are recognized as mediators of the immune response and may be a potential therapeutic target for the treatment of sepsis. We previously demo...

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Bibliographic Details
Main Authors: Denise C Cornelius, Olivia K Travis, Robert W Tramel, Marivee Borges-Rodriguez, Cedar H Baik, Mallory Greer, Chelsea A Giachelli, Geilda A Tardo, Jan M Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0234039

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https://doi.org/10.1371/journal.pone.0234039

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