Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review

Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review

Abstract Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration. Due to the complication of such a multifactorial disorder and significant limitations of the ther...

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Bibliographic Details
Main Authors: Tapan Behl, Gagandeep Kaur, Ovidiu Fratila, Camelia Buhas, Claudia Teodora Judea-Pusta, Nicoleta Negrut, Cristiana Bustea, Simona Bungau
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
Glycosylceramidase
Glucocerebrosidase
Gaucher’s disease
Mutations
α-Synuclein
Online Access:https://doi.org/10.1186/s40035-020-00226-x

Internet

https://doi.org/10.1186/s40035-020-00226-x

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