Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis.

Members of the Inhibitor of APoptosis (IAP) protein family suppress apoptosis within tumor cells, particularly in the context of immune cell-mediated killing by the tumor necrosis factor (TNF) superfamily cytokines. Most IAPs are opposed endogenously by the second mitochondrial activator of caspases...

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Bibliographic Details
Main Authors: Kate Welsh, Snezana Milutinovic, Robert J Ardecky, Marcos Gonzalez-Lopez, Santhi Reddy Ganji, Peter Teriete, Darren Finlay, Stefan Riedl, Shu-Ichi Matsuzawa, Clemencia Pinilla, Richard Houghten, Kristiina Vuori, John C Reed, Nicholas D P Cosford
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5019375?pdf=render

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http://europepmc.org/articles/PMC5019375?pdf=render

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