Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice

Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice

Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against renal injury, and prolongs mouse survival during seps...

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Bibliographic Details
Main Authors: Sooghee Chang, Youn-Hee Kim, Young-Joo Kim, Young-Woo Kim, Sungyoon Moon, Yong Yook Lee, Jin Sun Jung, Youngsoo Kim, Hi-Eun Jung, Tae-Joo Kim, Taek-Chin Cheong, Hye-Jung Moon, Jung-Ah Cho, Hang-Rae Kim, Dohyun Han, Yirang Na, Seung-Hyeok Seok, Nam-Hyuk Cho, Hai-Chon Lee, Eun-Hee Nam, Hyosuk Cho, Murim Choi, Nagahiro Minato, Seung-Yong Seong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
sepsis
myeloid-derived suppressor cells
taurodeoxycholate
TGR5
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01984/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01984/full

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