Inhibition of HMGB1 Suppresses Hepatocellular Carcinoma Progression via HIPK2-Mediated Autophagic Degradation of ZEB1

Inhibition of HMGB1 Suppresses Hepatocellular Carcinoma Progression via HIPK2-Mediated Autophagic Degradation of ZEB1

Autophagy is a conserved catabolic process maintaining cellular homeostasis and reportedly plays a critical role in tumor progression. Accumulating data show that autophagic activity is inhibited in hepatocellular carcinoma. However, the underlying molecular basis of impaired autophagy in HCC remain...

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Bibliographic Details
Main Authors: Wei Zhu, Jun Li, Yuheng Zhang, Zhengyi Zhu, Hanyi Liu, Yunzhen Lin, Anyin Hu, Jingchao Zhou, Haozhen Ren, Xiaolei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
hepatocellular carcinoma (HCC)
high-mobility group box 1 (HMGB1)
epithelial-mesenchymal transition (EMT)
autophagy
glucose metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.599124/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.599124/full

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