Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity...

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Bibliographic Details
Main Authors: Khaldoun Rifaï, Mouhamed Idrissou, Frédérique Penault-Llorca, Yves-Jean Bignon, Dominique Bernard-Gallon
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
breast cancer
SIRT1
deacetylation
epigenetic silencing
tumor promoter
tumor suppressor
SIRT1 modulators
Online Access:https://www.mdpi.com/2072-6694/10/11/409

Internet

https://www.mdpi.com/2072-6694/10/11/409

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