Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia

Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia

Septo-optic dysplasia (SOD) is a congenital disorder characterized by optic nerve, pituitary and midline brain malformations. The clinical presentation of SOD is highly variable with a poorly understood etiology. The majority of SOD cases are sporadic, but in rare instances inherited mutations have...

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Bibliographic Details
Main Authors: Benjamin M. Kahn, Tanya S. Corman, Korah Lovelace, Mingi Hong, Robert S. Krauss, Douglas J. Epstein
Format: Article
Language:English
Published: The Company of Biologists 2017-01-01
Series:Disease Models & Mechanisms
Subjects:
Optic nerve hypoplasia
Shh
Ethanol
Cdon
Septo-optic dysplasia
Online Access:http://dmm.biologists.org/content/10/1/29

Internet

http://dmm.biologists.org/content/10/1/29

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