Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70

A variety of natural compounds have been shown to modulate T cell receptor (TCR) activation, including natural sesquiterpene lactones (SLs). In the present studies, we evaluated the biological activity of 11 novel semi-synthetic SLs to determine their ability to modulate TCR activation. Of these com...

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Bibliographic Details
Main Authors: Andrei I. Khlebnikov, Igor A. Schepetkin, Anarkul S. Kishkentaeva, Zhanar R. Shaimerdenova, Gayane A. Atazhanova, Sergazy M. Adekenov, Liliya N. Kirpotina, Mark T. Quinn
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
sesquiterpene lactones
ZAP-70
T cell receptor
extracellular signal-regulated kinase
calcium flux
molecular modeling
glutathione
Online Access:http://www.mdpi.com/1420-3049/24/2/350

Internet

http://www.mdpi.com/1420-3049/24/2/350

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