Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice1[S]

Inhibition of myeloperoxidase decreases vascular oxidative stress and increases vasodilatation in sickle cell disease mice1[S]

Activated leukocytes and polymorphonuclear neutrophils (PMN) release myeloperoxidase (MPO), which binds to endothelial cells (EC), is translocated, and generates oxidants that scavenge nitric oxide (NO) and impair EC function. To determine whether MPO impairs EC function in sickle cell disease (SCD)...

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Bibliographic Details
Main Authors: Hao Zhang, Hao Xu, Dorothee Weihrauch, Deron W. Jones, Xigang Jing, Yang Shi, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard, Jr.
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Journal of Lipid Research
Subjects:
chlorotyrosine
malondialdehyde
L-selectin
polymorphonuclear cells
endothelial cells
liver
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520350525

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http://www.sciencedirect.com/science/article/pii/S0022227520350525

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