Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli

In E. coli, alternate peptidoglycan crosslinking reactions carried out by the L,D-transpeptidase YcbB can lead to beta-lactam resistance. Here, Caveney et al. solve the crystal structure of YcbB and shed light into its mechanism of action and into YcbB-mediated antibiotic resistance.

Bibliographic Details
Main Authors: Nathanael A. Caveney, Guillermo Caballero, Henri Voedts, Ana Niciforovic, Liam J. Worrall, Marija Vuckovic, Matthieu Fonvielle, Jean-Emmanuel Hugonnet, Michel Arthur, Natalie C. J. Strynadka
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09507-0

Internet

https://doi.org/10.1038/s41467-019-09507-0

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