Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Self-assembly of an anion receptor with metal-dependent kinase inhibition and potent in vitro anti-cancer properties

Artificial self-assembling systems such as anion receptors or ‘binders’ are largely unexplored for therapeutic applications. Here, the authors report self-assembling trimetallic cryptands containing copper, zinc or manganese that encapsulate a range of anions, are highly toxic to human cancer cell l...

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Bibliographic Details
Main Authors: Simon J. Allison, Jaroslaw Bryk, Christopher J. Clemett, Robert A. Faulkner, Michael Ginger, Hollie B. S. Griffiths, Jane Harmer, P. Jane Owen-Lynch, Emma Pinder, Heiko Wurdak, Roger M. Phillips, Craig R. Rice
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23983-3

Internet

https://doi.org/10.1038/s41467-021-23983-3

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