Evolutionary triplet models of structured RNA.

The reconstruction and synthesis of ancestral RNAs is a feasible goal for paleogenetics. This will require new bioinformatics methods, including a robust statistical framework for reconstructing histories of substitutions, indels and structural changes. We describe a "transducer composition&quo...

Full description

Bibliographic Details
Main Authors: Robert K Bradley, Ian Holmes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2725318?pdf=render