Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function

Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function

Activated phosphoinositide 3-kinase delta syndrome (APDS), also known as p110 delta-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI), is an autosomal dominant primary human immunodeficiency (PID) caused by heterozygous gain-of-function mutations in PIK3CD,...

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Bibliographic Details
Main Authors: Jennifer L. Cannons, Silvia Preite, Senta M. Kapnick, Gulbu Uzel, Pamela L. Schwartzberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
Epstein–Barr virus
activated phosphoinositide 3-kinase delta syndrome
p110δ activating mutation causing senescent T cells
lymphadenopathy and immunodeficiency
cytotoxic T lymphocyte
primary human immunodeficiency
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01758/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01758/full

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