An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

An Historical Overview: The Discovery of How NK Cells Can Kill Enemies, Recruit Defense Troops, and More

Natural killer (NK) cells were originally defined as effector lymphocytes of innate immunity characterized by the unique ability of killing tumor and virally infected cells without any prior priming and expansion of specific clones. The “missing-self” theory, proposed by Klas Karre, the seminal disc...

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Bibliographic Details
Main Authors: Massimo Vitale, Claudia Cantoni, Mariella Della Chiesa, Guido Ferlazzo, Simona Carlomagno, Daniela Pende, Michela Falco, Annamaria Pessino, Letizia Muccio, Andrea De Maria, Emanuela Marcenaro, Lorenzo Moretta, Simona Sivori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
human natural killer cells
innate immunity
natural cytotoxicity receptors
Toll-like receptors
activating NK receptors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01415/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01415/full

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