Myosin-X and talin modulate integrin activity at filopodia tips

Myosin-X and talin modulate integrin activity at filopodia tips

Summary: Filopodia assemble unique integrin-adhesion complexes to sense the extracellular matrix. However, the mechanisms of integrin regulation in filopodia are poorly defined. Here, we report that active integrins accumulate at the tip of myosin-X (MYO10)-positive filopodia, while inactive integri...

Full description

Bibliographic Details
Main Authors: Mitro Miihkinen, Max L.B. Grönloh, Ana Popović, Helena Vihinen, Eija Jokitalo, Benjamin T. Goult, Johanna Ivaska, Guillaume Jacquemet
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
Filopodia
integrin activity
adhesion
MYO10
talin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721011657

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721011657

Similar Items