Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

Abstract Background Individuals with impaired immunity are more susceptible to infections than immunocompetent subjects. No vaccines are currently available to induce protection against E. coli meningoencephalitis. This study evaluated the potential of poly(I:C) pre-treatment to induce trained immun...

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Bibliographic Details
Main Authors: Sandra Ribes, Christa Arcilla, Martina Ott, Sandra Schütze, Uwe-Karsten Hanisch, Stefan Nessler, Roland Nau
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Meningitis
Poly(I:C)
Trained innate immunity
NK cell
Microglia
IFN-γ
Online Access:https://doi.org/10.1186/s12974-020-1700-4

Internet

https://doi.org/10.1186/s12974-020-1700-4

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